Mucin1 utterance in oral squamous cell carcinoma: A cancer maker and target for nanotheranostics

Mucins are cell bound high molecular weight glycoproteins which secreted by epithelial cells. Total 21 mucin variants identified till date. Mucin1 (MUC1) is a transmembrane glycoprotein, when reacts with beta-catenin, can able to enter the nucleus activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression, after it may inhibit cell-cell cell-stroma interactions function as signal transducer, leading tumor progression. To compare correlate expression positive intensity of MUC1 in oral squamous carcinoma, dysplasia normal mucosa using Immunohistochemistry. This study included total 45 cases groups carcinoma (n=15), (n=15) control analysed for anti rabbit monoclonal antibody immunohistochemical technique. The mucin1 cells were follows, 53.3% OSCC, 13.3% OED none showed positivity mucosa. results obtained statistically Kruskal-Wallis test there was significant difference score between different tissue groups, Kruskal – Wallis H = 13.034, p 0.001. There progressive increase from OSCC. utterance might be due suppression inhibitory proteins immunoexpression mature atypical well proposed act both an anti-adhesive adhesive molecule.